Answer: a
Explanation: A histone variant CENP – A, is associated with the nucleosome that include
centromeric DNA. In this region CENP – A replaces H3 subunit in the nucleosomes. These
nucleosomes are incorporated into the kinetochore which mediates attachment of the chromosome
to the mitotic spindle. The extended tail of CENP – A may generate these novel binding sites for
other binding protein components of the kinetochore.
Shalini Rathod
Answer: a
Explanation: A histone variant CENP – A, is associated with the nucleosome that include
centromeric DNA. In this region CENP – A replaces H3 subunit in the nucleosomes. These
nucleosomes are incorporated into the kinetochore which mediates attachment of the chromosome
to the mitotic spindle. The extended tail of CENP – A may generate these novel binding sites for
other binding protein components of the kinetochore.
Shalini Rathod
Answer: a
Explanation: A histone variant CENP – A, is associated with the nucleosome that include
centromeric DNA. In this region CENP – A replaces H3 subunit in the nucleosomes. These
nucleosomes are incorporated into the kinetochore which mediates attachment of the chromosome
to the mitotic spindle. The extended tail of CENP – A may generate these novel binding sites for
other binding protein components of the kinetochore.