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Shalini Rathod
Shalini Rathod

Shalini Rathod

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Asked: 2021-07-29T11:14:10+05:30 In:

Which histone molecule produces novel binding sites for protein components of the kinetochore?

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Which histone molecule produces novel binding sites for protein components of the kinetochore?
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    1. Shalini Rathod

      Shalini Rathod

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      Answer: a
      Explanation: A histone variant CENP – A, is associated with the nucleosome that include
      centromeric DNA. In this region CENP – A replaces H3 subunit in the nucleosomes. These
      nucleosomes are incorporated into the kinetochore which mediates attachment of the chromosome
      to the mitotic spindle. The extended tail of CENP – A may generate these novel binding sites for
      other binding protein components of the kinetochore.

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    3. Shalini Rathod

      Shalini Rathod

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      Answer: a

      Explanation: A histone variant CENP – A, is associated with the nucleosome that include

      centromeric DNA. In this region CENP – A replaces H3 subunit in the nucleosomes. These

      nucleosomes are incorporated into the kinetochore which mediates attachment of the chromosome

      to the mitotic spindle. The extended tail of CENP – A may generate these novel binding sites for

      other binding protein components of the kinetochore.

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